Clinical Trial Finds Cannabis Oil is Well-Tolerated, Effective Insomnia Treatment

Many will attest to the sedative and relaxing effects of cannabis as a sleep aid, with countless additional studies. now, new research Published in Journal of Sleep Research Short-term use of plant-derived cannabis extracts found to be well-tolerated and effective for patients diagnosed with insomnia, adding additional insight into the benefits of cannabis for treating insomnia To do.

Insomnia, which involves difficulty falling asleep or staying asleep, is relatively common and is experienced by up to 30% of the general population. In their introduction, the authors point out the effects of individual cannabinoids on sleep, as well as the potential for cannabis to help alleviate sleep disturbances. Specifically, it mentions the sedative effects of THC and the potential for CBD to act as a sedative at high doses.

This trial aimed to evaluate the tolerability and efficacy of medicinal cannabis oil for sleep in adults with insomnia. It was conducted at a National Institute of Integrative Medicine. Researchers evaluated the use of cannabis oil products and a placebo in her 29 subjects with chronic insomnia.

Each extract contained 10mg of THC and 15mg of CBD per milliliter, as well as low amounts of other cannabinoids and naturally occurring terpenes, and each participant received either the extract or a placebo for 2 weeks. ingested. Participants were instructed to take the oil with food in the evening, increasing the dose by 0.1ml (THC 1mg/CBD 1.5mg) each day, starting with 0.2ml on the first day and up to 1.5ml (HC 15mg). / 22.5mg). mg CBD).

The 6-week study consisted of a 1-week run-in period, a 2-week intervention period, a 1-week washout period, and a 2-week secondary intervention period, with a total of 4 assessments at the beginning and end. I was. of each intervention stage. Primary endpoints included salivary melatonin levels and insomnia symptoms as assessed by the ISI questionnaire.

Ultimately, the researchers found that participants who used the cannabis extract had up to 80% improved sleep quality, and 60% of the participants were no longer classified as having clinical insomnia at the end of the two-week intervention period. Reported. Four of his total participants (14%) had no side effects, but 24 (83%) had non-serious side effects, such as dry mouth, diarrhea, nausea, and dizziness, probably related to active medications. reported.

The researchers also experienced all side effects, with the exception of dry mouth, for only one or two non-consecutive days. Twenty percent discontinued dose escalation at 0.4-0.6 ml due to side effects such as dizziness or dizziness. reported dizziness, both of which were relieved by lowering the dose.

At the end of the trial, all but one participant (96%) found cannabis oil to be an acceptable treatment for insomnia, and the majority of participants (79%) were willing to continue medicinal cannabis oil. I requested a prescription. Tachycardia. Of the six participants who chose not to continue taking cannabis oil, five cited reasons other than side effects (work restrictions, driving, etc.) as reasons for discontinuing treatment.

“Our short-term studies suggest Entoura 10:15 medicinal cannabis oil with THC:CBD 10:15 and small amounts of other ingredients. [cannabinoids] The researchers concluded that it was well tolerated and effective enough to significantly improve sleep quality and duration, midnight melatonin levels, quality of life and mood in adults with insomnia within two weeks. “Long-term studies are needed to assess whether chronic medicinal cannabis consumption can restore natural circadian rhythms without the need for continuous cannabis consumption.”