Data Finds Hemp Hulls Contain Bioactive Compounds Supporting Gut Health

Hemp has many industrial uses, and while some consumers may tout the benefits of consuming hemp for constipation, high cholesterol, eczema, arthritis, and other conditions, these Evidence to support its use is still limited.

Brightseed, a biosciences and artificial intelligence company, has published preclinical, peer-reviewed data. Journal of Food Bioactives, last week. This finding suggests that two bioactive compounds found in the husk of hemp – N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT) – may support intestinal barrier function. is shown.

Hemp Gut Health Links

Bioactive compounds are a class of chemicals found in foods such as fruits, vegetables, nuts, oils, and whole grains that have health-promoting effects in the body. These compounds are often studied for their potential to prevent disease. Although it is scientifically known that bioactive substances can have significant effects on our health, the majority of bioactive compounds are still unknown, hence the term “nutritional dark matter”. It is sometimes called

Gut health is related to the immune system, the central nervous system, and the enteric nervous system. Therefore, it can be related to the overall health of the body. The intestinal barrier allows the body to take in essential nutrients and immunosensing while limiting pathogenic molecules, toxins, and bacteria. It’s called a “leaky gut” and can be a symptom of an impaired gut health.

In this in vitro study using Brightseed’s Forager AI platform, proliferating human transverse colon epithelial cells were implanted and co-cultured with NCT, NFT, or NCT/NFT along with tumor necrosis factor (TNF) for 48 hours. The researchers found that the addition of TNF decreased transepithelial electrical resistance (TEER), increased intestinal permeability, and caused symptoms of leaky gut, while co-administration of NCT and NFT reduced TEER. reported a dose-dependent and statistically significant reversal of impairment and intestinal dysfunction. transparency.

“This publication is the latest validation of Bright Seed’s approach to discovering nature’s solutions to restore human health. press release“These insights into how NCTs and NFTs can support intestinal function, particularly intestinal barrier strength by restoring a healthy epithelial barrier, are valuable for personalized and proactive health solutions.” provides a strong foundation for ongoing clinical studies to demonstrate the benefits of natural ingredients in

Discover bioactive compounds using AI

Brightseed’s Forager identified the activity of two bioactive compounds against key biological receptors that govern gut health. NCTs and NFTs have also been shown to act as agonists of the HNF4a protein. The HNF4a protein, when expressed in the gut, is associated with a high-fat diet and may be associated with poor gut health and reduced gut barrier integrity.

Forager scoured the plant kingdom for new sources of these two bioactive compounds and identified hemp husks as one of the most abundant sources.Brightseed launched last fall Bright Seed Bio 01is hemp fiber for food and beverage use and contains NCTs and NFTs to support intestinal strength and intestinal lining to maintain healthy intestinal barrier function. Formulated to optimize bioactive ingredients while retaining

Brightseed COO and co-founder Sofia Elizondo similarly expressed excitement, saying Brightseed intends to continue with similar insights as it develops “a portfolio of bioactive ingredients that meet important consumer health areas.” said there is.

“Brightseed’s focus on computational bioactivity discovery combined with advanced metabolomics will help the functional food, beverage, and nutraceutical industries realize the potential of bioactive substances for human health. You can get the most out of it,” added Elizondo.