High-THC Flower Yields Few Serious Side Effects in Patients

High-THC Flower Yields Few Serious Side Effects in Patients

Research results published in the journal drug psychiatrydebunks claims that high-THC cannabis poses unique health risks, based on an online survey of more than 1,000 patients in Germany between June 2020 and August 2020.

“Patients were only allowed to participate if they received cannabis-based treatment from a pharmacy in the form of cannabis flower prescribed by a doctor,” the researchers explained.

“Overall, the mean patient-reported efficacy was 80.1% (range, 0-100%). Regression models revealed no association between patient-reported efficacy and diversity. Additionally, illness does not affect your choices. [medical cannabis] Strain detected. On average, 2.1 side effects were reported (the most common were dry mouth (19.5%), increased appetite (17.1%), and fatigue (13.0%)). However, his 29% of participants reported no side effects. Only 398 participants (38.7%) [medical cannabis] It was covered by health insurance,” they continued.

The researchers said patients “self-reported very good efficacy and tolerability” of medical cannabis and “there was no evidence to suggest specific efficacy and tolerability.” [medical cannabis] Depending on the disease you are treating, you will get a good strain. ”

This finding is notable considering that in Europe, “pharmaceutical-grade cannabis flower…contains THC levels of 20 percent or more.” According to NORML.

NORML said the findings “refute claims that cannabis strains with high THC content pose unique health risks and that there is no research to support the effectiveness of medical cannabis chemovars containing more than 10 percent THC. ”.

Researchers behind the study said they were prompted to investigate this issue because of the lack of research involving highly potent medical cannabis. They said their findings were “the first large-scale study investigating the efficacy and tolerability of different cannabis strains prescribed by German doctors.”

“There is increasing evidence that cannabis-based medicine (CBM) is effective for a variety of indications, primarily chronic pain, multiple sclerosis spasticity, and palliative care. Available after reintroduction into medicine The number and variety of CBMs continued to increase, from pure tetrahydrocannabinol (THC) to pure cannabidiol (CBD), and even cannabis extracts and flowers with very different THC:CBD ratios. Cannabis flower and extracts were legalized for medical purposes in Germany in 2017. In limited exceptional cases and after approval (under social insurance law), the costs are covered by health insurance. Currently (as of 2023) more than 150 types of cannabis flower can be prescribed in Germany. However, there are specific strains and different concentrations of THC, CBD, other cannabinoids, and other components, including terpenes and flavonoids. “However, it is largely unknown whether this results in different efficacy under different conditions,” the researchers said.

“To date, only a limited number of studies have directly compared the effects of different cannabis strains in different indications. Over 600 people registered with the Vancouver Island Compassion Society and treated with medical cannabis (MC) Data collected from 2009 to 2010 from human patients showed that the “more popular” cannabis indica strains were more effective in reducing pain compared to C. sativa strains. Several characteristics were found to be similar in both species. For example, confidence in purity, route of administration, reason for use (recreational or medical). ”

Still, the researchers also noted the limitations of their findings and cautioned against drawing too sweeping conclusions.

“We could not confirm our main hypothesis that certain cannabis strains are more effective in certain indications. Also, there was no effect of each indication on MC strain selection,” they said. “With the exception of one strain, all of the strains preferred by participants were THC-dominant and had high THC concentrations. The efficacy and tolerability of MC for the treatment of a variety of self-reported medical conditions was excellent. There were no relevant differences between C. sativa, indica, or hybrids. The majority of patients used cannabis not only for MC prescribed by a doctor for many years, but also for self-medication. The overall aroma and taste profile was rated as very good, while the average value for money was rated as poor, which is probably due to the majority of patients. This may be because he did not receive any cost compensation from his health insurance.

Other limitations of this study include: “(i) only German-speaking patients were included; (ii) most participants were from Germany, so the data only represented a small geographic area; iii) it only includes data for MC stocks that are available in German. Pharmacies in 2020 may be collected. (iv) the data were collected online based on self-reported diagnosis and treatment efficacy, and (v) we cannot completely exclude the possibility that participants provided false information. ”

However, the study “also has some strengths,” the researchers said, noting that “the sample size was large…the recruitment time was relatively short…only patients who used MC from a physician-prescribed pharmacy were included. “…it involves a wide range of patients with a variety of indications…it takes a relatively long time.” The use of MC…and the use of an average of 5.9 different MC strains allows comparisons regarding clinical efficacy. ”

Alexandra Solorio
Introducing Alexandra, an accomplished cannabis writer who has passionately pursued her craft for a decade. Through a decade-long journey, Alexandra has cultivated a profound connection with the cannabis world, translating her expertise into captivating prose. From unraveling the plant's rich history to exploring its therapeutic marvels and legal evolution, she has adeptly catered to both connoisseurs and newcomers. An unwavering advocate, Alexandra's words not only enlighten but also advocate responsible cannabis use, establishing her as an indispensable industry voice over the past ten years.

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